Lee Kap No, Suh In Bum, Chang Eun Ah, Kim Soon Duck, Cho Nam Sun, Park Phil Whan, An Seong Soo A, Park Ok, Lim Chaeseung
Department of Laboratory Medicine, Brain Korea 21 Graduate School of Medicine, Korea University, Ansan City, South Korea.
Trop Med Int Health. 2003 Dec;8(12):1062-7. doi: 10.1046/j.1360-2276.2003.01136.x.
Malaria has recently re-emerged in the Republic of Korea (ROK), but only few malaria seroprevalences were reported. We obtained 1014 serum samples from inhabitants of five regions of ROK during the high transmission season between June and August in 2001. The levels of anti-circumsporozoite protein (CSP) antibody were assessed in samples using an indirect enzyme-linked immunosorbent assay (ELISA). The highest IgG seroreactivity against Plasmodium vivax recombinant CSP antigen was found among male residents of Cheolwon gun (13.5%), then Incheon (4.7%). The IgG seroreactivity from other regions ranged from 0.0% to 2.0%. These epidemiological data of seroprevalence in five regions of Korea showed a similar pattern to the annual incidence of malaria in these respective regions. The prevalence of antibodies increased with age, suggesting that the age and area-related prevalence patterns reflected differences in the inoculation rates between age groups and geographic regions. Seroprevalence and annual incidence were positively correlated in some areas of Korea.
疟疾最近在大韩民国（韩国）再度出现，但报告的疟疾血清阳性率却很少。2001年6月至8月的高传播季节期间，我们从韩国五个地区的居民那里获取了1014份血清样本。使用间接酶联免疫吸附测定法（ELISA）评估样本中抗环子孢子蛋白（CSP）抗体的水平。在铁原郡的男性居民中发现针对间日疟原虫重组CSP抗原的最高IgG血清反应性（13.5%），其次是仁川（4.7%）。其他地区的IgG血清反应性范围为0.0%至2.0%。韩国五个地区的这些血清阳性率流行病学数据显示出与这些地区各自疟疾年发病率相似的模式。抗体患病率随年龄增加，这表明与年龄和地区相关的患病率模式反映了不同年龄组和地理区域之间接种率的差异。在韩国的一些地区，血清阳性率与年发病率呈正相关。
