Beal S M
Adelaide Children's Hospital, South Australia, Australia.
Clin Perinatol. 1992 Dec;19(4):839-48.
The overall low recurrence rate of SIDS (< 2%) and the lack of concordance in twins are against SIDS being a genetic disorder. The most likely explanations for an increased incidence in siblings are that SIDS constitutes a mixed group of disorders that includes some genetic diseases and some disorders that are known to be recurrent but not genetic, and that some recurrences occur in families in whose lives there is severe deprivation, with many risk factors for SIDS, and in other families whose infant care practices, while not being overtly wrong, increase the risk of SIDS. With improving identification and management of these disorders and risk factors, it is expected that the incidence of SIDS, and, particularly, recurrent incidence in a family, will decrease. The best advice that can be given to families who have had an infant die from SIDS is that for most families the risk of another death from SIDS is very low (< 1%) and that if SIDS does recur, there will not be a prolonged period of suffering for the child. With this information and the recognition by most families that they do not regret having had the child who died, most families are prepared to welcome another pregnancy.
婴儿猝死综合征(SIDS)总体复发率较低(<2%),且双胞胎之间缺乏一致性,这表明SIDS并非遗传性疾病。兄弟姐妹中发病率增加的最可能原因是,SIDS是一组混合性疾病,其中包括一些遗传性疾病和一些已知会复发但非遗传性的疾病,而且一些复发发生在生活中存在严重贫困、有许多SIDS风险因素的家庭,以及其他婴儿护理方式虽无明显错误但会增加SIDS风险的家庭。随着对这些疾病和风险因素的识别与管理得到改善,预计SIDS的发病率,尤其是家庭中的复发率将会降低。对于有婴儿死于SIDS的家庭,所能给出的最佳建议是,对大多数家庭来说,再次死于SIDS的风险非常低(<1%),而且如果SIDS确实复发,孩子也不会遭受长时间的痛苦。有了这些信息,并且大多数家庭认识到他们并不后悔生下夭折的孩子,大多数家庭都愿意迎接再次怀孕。