Mervaala E, Nousiainen U, Kinnunen J, Vapalahti M, Riekkinen P
Department of Clinical Neurophysiology, Vaajasalo Hospital, Kuopio, Finland.
Epilepsia. 1992 Nov-Dec;33(6):1029-35. doi: 10.1111/j.1528-1157.1992.tb01754.x.
We studied auditory event-related potentials (ERPs) in 11 surgically treated patients with intractable temporal lobe epilepsy (TLE) pre- and postoperatively. ERPs through sphenoidal electrodes (Sp1-T3, Sp2-T4) provided clinically relevant and correctly lateralizing electrophysiologic evidence of temporal lobe dysfunction in 9 of 11 patients, confirmed by EEGs, electrocorticograms, neuroradiologic, and neuropsychological results, and clinical follow-up. Lateralizing asymmetries were noted in P300 amplitude, but latencies were prolonged bilaterally. Sphenoidal ERPs might serve as a new functional indicator of temporal lobe dysfunction in patients evaluated for epilepsy surgery.
我们对11例接受手术治疗的顽固性颞叶癫痫（TLE）患者在术前和术后进行了听觉事件相关电位（ERP）研究。通过蝶骨电极（Sp1-T3，Sp2-T4）记录的ERP在11例患者中的9例中提供了与临床相关且能正确定位颞叶功能障碍的电生理证据，这一结果得到了脑电图、皮质电图、神经放射学、神经心理学结果以及临床随访的证实。在P300波幅上观察到了定位不对称，但双侧潜伏期均延长。蝶骨电极ERP可能成为评估癫痫手术患者颞叶功能障碍的一种新的功能指标。
