Tuunainen A, Nousiainen U, Pilke A, Mervaala E, Riekkinen P
Department of Clinical Neurophysiology, Vaajasalo Hospital, Finland.
Epilepsia. 1995 Mar;36(3):262-9. doi: 10.1111/j.1528-1157.1995.tb00994.x.
The effect of short-term withdrawal of antiepileptic drugs (AEDs) on auditory event-related potentials (ERPs) was studied in 16 patients undergoing preoperative evaluation for epilepsy surgery. ERPs were performed for all patients during treatment with full medication and after a 1-week period during ongoing tapering of AEDs. To clarify whether AED discontinuation would provide evidence of lateralizing for ERPs, we also studied the subgroup of 9 patients who had already undergone temporal lobectomies (TLE group). In the TLE group, if habitual seizures occurred < 30 h before the ERP recording session, auditory N1 and P3 amplitudes across sphenoidal electrodes were markedly decreased on the side ipsilateral to the epileptic focus. If seizures did not occur, asymmetries in amplitudes were equivocal and not of lateralizing value. In the whole group, midline N1 latencies for standard responses decreased significantly during AED discontinuation. At baseline, long-term habituation of the N1 component for standard responses was attenuated as compared with that of controls. During AED discontinuation, however, enhanced habituation of N1 was observed in TLE patients who did not exhibit seizures before ERP recording.
在16例接受癫痫手术术前评估的患者中，研究了短期停用抗癫痫药物（AEDs）对听觉事件相关电位（ERPs）的影响。在所有患者全剂量用药治疗期间以及AEDs逐渐减量1周后进行ERPs检测。为了明确停用AEDs是否能为ERPs提供定侧依据，我们还对9例已接受颞叶切除术的患者亚组（颞叶癫痫组）进行了研究。在颞叶癫痫组中，如果在ERP记录前<30小时出现惯常发作，蝶骨电极同侧的听觉N1和P3波幅明显降低。如果未发作，波幅不对称不明确且无定侧价值。在整个研究组中，停用AEDs期间标准反应的中线N1潜伏期显著缩短。基线时，与对照组相比，标准反应的N1成分长期习惯化减弱。然而，在ERP记录前未发作的颞叶癫痫患者停用AEDs期间，观察到N1习惯化增强。
