Williams J, Rausch R
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Epilepsia. 1992 Nov-Dec;33(6):1036-41. doi: 10.1111/j.1528-1157.1992.tb01755.x.
The intracarotid amobarbital procedure (IAP) is frequently used to determine hemispheric language dominance and memory competence in individuals with intractable epilepsy before surgical intervention. The present study focused on outcome results concerning use of this technique in children. The IAP was an effective tool in determining their hemispheric language dominance. Seven characteristics, including age, gender, dose level of sodium amobarbital, Full-Scale I.Q., hemispheric side of injection (left or right), language dominance of hemisphere injected, and order of injection (first or second) were examined as possible factors predictive of memory performance on the IAP. Results suggest that after injection of the hemisphere suspected of containing the primary seizure origin, children aged < 13 years who had the left language-dominant hemisphere injected were significantly less likely to pass IAP memory tasks than were older children or younger children who had the nondominant hemisphere injected. These findings suggest that the IAP is a reliable indicator of hemispheric memory competence in children aged > 13 years or younger children whose suspected seizure focus is located in the nondominant language hemisphere.
颈内动脉阿米妥试验（IAP）常用于在手术干预前确定难治性癫痫患者的半球语言优势和记忆能力。本研究聚焦于该技术在儿童中的应用结果。IAP是确定儿童半球语言优势的有效工具。研究考察了七个特征，包括年龄、性别、阿米妥钠剂量水平、全量表智商、注射半球侧（左或右）、注射半球的语言优势以及注射顺序（第一或第二），作为IAP记忆表现的可能预测因素。结果表明，在注射疑似包含原发性癫痫发作起源的半球后，年龄<13岁且注射左侧语言优势半球的儿童通过IAP记忆任务的可能性明显低于年龄较大的儿童或注射非优势半球的年幼儿童。这些发现表明，IAP是年龄>13岁或疑似癫痫病灶位于非优势语言半球的年幼儿童半球记忆能力的可靠指标。
