Nejentsev Sergey, Guja Cristian, McCormack Rose, Cooper Jason, Howson Joanna M M, Nutland Sarah, Rance Helen, Walker Neil, Undlien Dag, Ronningen Kjersti S, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Ionescu-Tirgoviste Constantin, Gale Edwin A M, Bingley Polly J, Gillespie Kathleen M, Savage David A, Carson Dennis J, Patterson Chris C, Maxwell A Peter, Todd John A
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, CB2 2XY, Cambridge, UK.
Lancet. 2003 Nov 22;362(9397):1723-4. doi: 10.1016/S0140-6736(03)14847-7.
Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.
细胞间黏附分子-1（ICAM-1）通过其配体白细胞整合素发挥作用，参与免疫细胞与内皮细胞的黏附以及T细胞活化过程。其第三个免疫球蛋白样细胞外结构域可结合整合素Mac-1，且存在一个常见的非保守氨基酸多态性位点G241R。从表型上看，ICAM-1与1型糖尿病（一种T细胞介导的自身免疫性疾病）有关。我们评估了两个独立数据集，发现与G241相比，R241与1型糖尿病风险较低相关（3695个家庭，相对风险0.91，p = 0.03；446个家庭，0.60，p = 0.006）。我们的数据表明ICAM-1在1型糖尿病的病因学中起作用，这需要在未来的基因和功能实验中得到证实。
