Nishimura M, Obayashi H, Maruya E, Ohta M, Tegoshi H, Fukui M, Hasegawa G, Shigeta H, Kitagawa Y, Nakano K, Saji H, Nakamura N
Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto, Japan.
Hum Immunol. 2000 May;61(5):507-10. doi: 10.1016/s0198-8859(00)00101-4.
We investigated the intercellular adhesion molecule-1 (ICAM-1) gene polymorphism in 90 patients with young-onset type 1 diabetes, 74 with adult-onset type 1 diabetes, and 171 control subjects. The distribution of C-T genotypes and allele frequencies in exon 6 of the ICAM-1 gene was significantly different between adult-onset type 1 diabetes patients and controls (chi(2) = 9.76, p = 0.0076), and between patients with adult-onset and young-onset type 1 diabetes (chi(2) = 11.28, p = 0.0036). In contrast, we failed to detect any association between patients with young-onset type 1 diabetes and controls. Our data suggest that ICAM-1 exon 6 gene polymorphism affects the age-at-onset of type 1 diabetes and that different pathogenetic mechanisms may exist between young-onset and adult-onset type 1 diabetes.
我们对90例早发型1型糖尿病患者、74例成人发病型1型糖尿病患者和171名对照者进行了细胞间黏附分子-1（ICAM-1）基因多态性研究。ICAM-1基因第6外显子的C-T基因型分布和等位基因频率在成人发病型1型糖尿病患者与对照者之间存在显著差异（χ² = 9.76，p = 0.0076），在成人发病型和早发型1型糖尿病患者之间也存在显著差异（χ² = 11.28，p = 0.0036）。相比之下，我们未检测到早发型1型糖尿病患者与对照者之间存在任何关联。我们的数据表明，ICAM-1第6外显子基因多态性影响1型糖尿病的发病年龄，并且早发型和成人发病型1型糖尿病之间可能存在不同的发病机制。
