M1:03 Rolf Luft Center for Diabetes and Endocrinology Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Stockholm, Sweden.
Front Endocrinol (Lausanne). 2013 Jan 22;3:179. doi: 10.3389/fendo.2012.00179. eCollection 2012.
Diabetes and diabetic nephropathy are complex diseases affected by genetic and environmental factors. Identification of the susceptibility genes and investigation of their roles may provide useful information for better understanding of the pathogenesis and for developing novel therapeutic approaches. Intercellular adhesion molecule 1 (ICAM1) is a cell surface glycoprotein expressed on endothelial cells and leukocytes in the immune system. The ICAM1 gene is located on chromosome 19p13 within the linkage region of diabetes. In the recent years, accumulating reports have implicated that genetic polymorphisms in the ICAM1 gene are associated with diabetes and diabetic nephropathy. Serum ICAM1 levels in diabetes patients and the icam1 gene expression in kidney tissues of diabetic animals are increased compared to the controls. Therefore, ICAM1 may play a role in the development of diabetes and diabetic nephropathy. In this review, we present genomic structure, variation, and regulation of the ICAM1 gene, summarized genetic and biological studies of this gene in diabetes and diabetic nephropathy and discussed about the potential application using ICAM1 as a biomarker and target for prediction and treatment of diabetes and diabetic nephropathy.
糖尿病和糖尿病肾病是受遗传和环境因素影响的复杂疾病。鉴定易感基因及其作用可能为更好地了解发病机制和开发新的治疗方法提供有用的信息。细胞间黏附分子 1（ICAM1）是一种在免疫系统的内皮细胞和白细胞表面表达的细胞表面糖蛋白。ICAM1 基因位于 19 号染色体 p13 上，位于糖尿病的连锁区域内。近年来，越来越多的报道表明，ICAM1 基因的遗传多态性与糖尿病和糖尿病肾病有关。与对照组相比，糖尿病患者的血清 ICAM1 水平和糖尿病动物肾脏组织中的 icam1 基因表达增加。因此，ICAM1 可能在糖尿病和糖尿病肾病的发展中起作用。在这篇综述中，我们介绍了 ICAM1 基因的基因组结构、变异和调控，总结了该基因在糖尿病和糖尿病肾病中的遗传和生物学研究，并讨论了将 ICAM1 作为预测和治疗糖尿病和糖尿病肾病的生物标志物和靶标的潜在应用。
