三种不同可注射水硬性磷酸钙骨水泥的体内行为

In vivo behavior of three different injectable hydraulic calcium phosphate cements.

作者信息

Apelt D, Theiss F, El-Warrak A O, Zlinszky K, Bettschart-Wolfisberger R, Bohner M, Matter S, Auer J A, von Rechenberg B

机构信息

MSRU, Equine Department, Faculty of Veterinary Medicine, University of Zurich, Winterthurerstr. 260, CH-8057 Zurich, Switzerland.

出版信息

Biomaterials. 2004 Mar-Apr;25(7-8):1439-51. doi: 10.1016/j.biomaterials.2003.08.073.

DOI:10.1016/j.biomaterials.2003.08.073

PMID:14643619

Abstract

Two dicalcium phosphate dihydrate (DCPD) hydraulic cements and one apatite hydraulic cement were implanted in epiphyseal and metaphyseal, cylindrical bone defects of sheep. The in vivo study was performed to assess the biocompatibility of the DCPD cements, using the apatite cement as control. After time periods of 2, 4 and 6 months the cement samples were clinically and histologically evaluated. Histomorphometrically the amount of new bone formation, fibrous tissue and the area of remaining cement were measured over time. In all specimens, no signs of inflammation were detectable either macroscopically or microscopically. All cements were replaced by different amounts of new bone. The two DCPD-cements showed the highest new bone formation and least cement remnants at 6 months, whereas the apatite was almost unchanged over all time periods.

摘要

将两种二水磷酸二钙（DCPD）水硬性骨水泥和一种磷灰石水硬性骨水泥植入绵羊的骨骺和干骺端圆柱形骨缺损处。进行体内研究以评估DCPD骨水泥的生物相容性，使用磷灰石骨水泥作为对照。在2、4和6个月的时间段后，对骨水泥样本进行临床和组织学评估。通过组织形态计量学方法，测量随时间推移新骨形成量、纤维组织量以及剩余骨水泥的面积。在所有标本中，无论宏观还是微观上均未检测到炎症迹象。所有骨水泥均被不同量的新骨替代。两种DCPD骨水泥在6个月时显示出最高的新骨形成量和最少的骨水泥残余物，而磷灰石在所有时间段内几乎没有变化。