Bini Marcella, Bruni Giovanna, Sturini Michela, Rossetti Beatrice, Alaimo Gianluca, Auricchio Ferdinando, Friuli Valeria, Maggi Lauretta
Chemistry Department, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy.
Consorzio per i Sistemi a Grande Interfase (CSGI), Via Della Lastruccia 3, 50019 Sesto Fiorentino, Italy.
Materials (Basel). 2025 Feb 27;18(5):1065. doi: 10.3390/ma18051065.
The increase in life expectancy has led to a rise of musculoskeletal disorders. Calcium phosphate cements (CPCs), thanks to some amazing features such as the ability to harden in vivo, bioactivity, and resorbability, are promising candidates to treat these diseases, notwithstanding their poor mechanical properties. We aimed to synthesise pure and barium- or silicon-doped brushite-based CPCs loaded with piroxicam to study the effects of the substitution on physical-chemical and pharmaceutical properties before and after cement immersion in phosphate buffer for different time periods. Our results demonstrated that piroxicam became amorphous in the hardened cements. The dopants did not change the brushite structure or its lamellar morphology, while both Ba and Si additions improved the initial Young's modulus compared to the pure cement, and the opposite trend was observed for compressive strength. Both the compressive strength and the elastic modulus decreased for the samples immersed in solution compared to the non-immersed samples, with stabilisation as the number of days increased. After 7 days, the whole drug amount was released, with a slower and constant kinetic for the Ba-doped cements compared to the pure and Si-doped ones.
预期寿命的增加导致了肌肉骨骼疾病的增多。磷酸钙骨水泥（CPCs）因其具有一些惊人的特性，如在体内硬化的能力、生物活性和可吸收性，尽管其力学性能较差，但仍是治疗这些疾病的有前景的候选材料。我们旨在合成负载吡罗昔康的纯的以及掺杂钡或硅的透钙磷石基CPCs，以研究在不同时间段将骨水泥浸泡在磷酸盐缓冲液中前后，这种取代对物理化学和药物性质的影响。我们的结果表明，吡罗昔康在硬化的骨水泥中变成了无定形。掺杂剂没有改变透钙磷石的结构或其层状形态，而与纯骨水泥相比，钡和硅的添加均提高了初始杨氏模量，而抗压强度则呈现相反的趋势。与未浸泡的样品相比，浸泡在溶液中的样品的抗压强度和弹性模量均降低，且随着天数增加而趋于稳定。7天后，全部药物量释放完毕，与纯的和掺杂硅的骨水泥相比，掺杂钡的骨水泥释放动力学更缓慢且恒定。
