University of Zurich, Switzerland.
Eur J Pharm Biopharm. 2013 Sep;85(1):130-8. doi: 10.1016/j.ejpb.2013.04.013. Epub 2013 May 13.
Four cement applications were tested in this investigation. Two dicalcium phosphate dihydrate (DCPD-brushite) hydraulic cements, an apatite hydraulic fiber loaded cement, and a calcium sulfate cement (Plaster of Paris) were implanted in epiphyseal and metaphyseal cylindrical bone defects in sheep. The in vivo study was performed to assess the biocompatibility and bone remodeling of four cement formulations. After time periods of 2, 4, and 6 months, the cement samples were clinically and histologically evaluated. Histomorphometrically, the amount of new bone formation, fibrous tissue, and bone marrow and the area of remaining cement were measured. In all specimens, no signs of inflammation were detectable either macroscopically or microscopically. Cements differed mainly in their resorption time. Calcium sulfate was already completely resorbed at 2 months and showed a variable amount of new bone formation and/or fibrous tissue in the original drill hole over all time periods. The two DCPD cements in contrast were degraded to a large amount at 6 months, whereas the apatite was almost unchanged over all time periods.
本研究共测试了四种水泥应用。两种二水磷酸氢钙（brushite）液压水泥、一种载有羟磷灰石的液压纤维水泥和一种硫酸钙水泥（熟石膏）被植入绵羊的骺端和骨干的圆柱形骨缺损中。进行体内研究以评估四种水泥配方的生物相容性和骨重塑。在 2、4 和 6 个月的时间点，对水泥样本进行临床和组织学评估。通过组织形态计量学，测量新骨形成、纤维组织和骨髓的量以及剩余水泥的面积。在所有标本中，无论是宏观还是微观都没有发现炎症迹象。水泥之间的主要区别在于其吸收时间。硫酸钙在 2 个月时已完全吸收，在所有时间段内，在原始钻孔中均显示出不同数量的新骨形成和/或纤维组织。相比之下，两种 DCPD 水泥在 6 个月时降解到大量，而羟磷灰石在所有时间段内几乎没有变化。
