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[胆石症与原发性胆汁性肝硬化合并胆汁淤积性黄疸]

[Combined cholestatic jaundice due to cholelithiasis and primary biliary cirrhosis].

作者信息

Heinrich I, Nashitz J, Yeshurun D

机构信息

Dept. of Medicine A, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa.

出版信息

Harefuah. 1992 Nov 15;123(10):392-4, 435.

PMID:1464385
Abstract

An 82-year-old man was admitted because of painless jaundice and pruritus. Multiple small gallstones were seen on ultrasonography. Hepatic needle biopsy revealed bile stasis, intrahepatic bile ducts proliferation and inflammatory infiltration of the portal spaces. As the jaundice deepened, cholecystectomy was performed and a gallbladder full of small calculi was removed. Wedge biopsy of the liver led to the diagnosis of primary biliary cirrhosis (PBC). Colchicine was started and since then his condition has improved and become stable. PBC in an old man is very uncommon. The combination with gallbladder stones imposed special diagnostic and therapeutic problems. Although gallbladder stones are more common in PBC than in the general population, the combination of the 2 clinical entities is not sufficiently emphasized in the literature.

摘要

一名82岁男性因无痛性黄疸和瘙痒入院。超声检查发现多个小胆结石。肝穿刺活检显示胆汁淤积、肝内胆管增生和门管区炎症浸润。随着黄疸加深,进行了胆囊切除术,切除了一个充满小结石的胆囊。肝脏楔形活检确诊为原发性胆汁性肝硬化(PBC)。开始使用秋水仙碱治疗,此后他的病情有所改善并趋于稳定。老年男性患PBC非常罕见。合并胆囊结石带来了特殊的诊断和治疗问题。虽然PBC患者中胆囊结石比普通人群更常见,但这两种临床情况的合并在文献中并未得到充分强调。

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