Andrews Paul D, Knatko Elena, Moore William J, Swedlow Jason R
Division of Gene Expression and Regulation, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK.
Curr Opin Cell Biol. 2003 Dec;15(6):672-83. doi: 10.1016/j.ceb.2003.10.013.
Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.
极光激酶最近在关键细胞周期进程的调控中占据了核心地位。极光A正成为中心体和纺锤体功能的关键调节因子。极光B通过确保姐妹染色单体的正确双定向来介导染色体分离，这可能是通过调节微管动力学实现的。这种酶显然还通过与一种关键的GTP酶和一种驱动蛋白样蛋白相互作用，在胞质分裂中发挥作用。最近对这两种激酶的研究揭示了极光激酶活性与细胞分裂机制之间的功能联系。
