de Araujo Souza Patricia Savio, Villa Luisa Lina
Ludwig Institute for Cancer Research, R. Prof. Antônio Prudente 109, 4 degrees andar, 01509-010 São Paulo, SP, Brazil.
Mutat Res. 2003 Nov;544(2-3):375-83. doi: 10.1016/j.mrrev.2003.06.013.
Human papillomavirus (HPV) is considered to be a necessary but not sufficient cause for cervical cancer and, therefore, other factors contribute to the carcinogenic process. A hereditary component for this neoplasia has been reported and several studies indicate that genetic background of the host is important for cervical cancer susceptibility. Among genetic factors that could participate in the susceptibility to this tumor and disease outcome, polymorphic genes of the major histocompatibility complex (MHC), as well as a particular polymorphism in the p53 gene have been intensely investigated. From our analysis of 613 samples in Brazil, we found evidence to indicate that different polymorphic human leukocyte antigen (HLA) genes are involved in the clearance and maintenance of HPV infection. In addition, the homozygous codon 72 p53-Arg gene allele is associated with susceptibility to HPV-associated cervical carcinogenesis. However, supportive and opposing data have been reported in different populations. Therefore, international collaborative studies need to be conducted to define the consistency of the associations described.
人乳头瘤病毒（HPV）被认为是宫颈癌发生的必要但非充分病因，因此，其他因素也参与了致癌过程。已有报道称这种肿瘤存在遗传因素，多项研究表明宿主的遗传背景对宫颈癌易感性很重要。在可能参与该肿瘤易感性和疾病转归的遗传因素中，主要组织相容性复合体（MHC）的多态性基因以及p53基因的特定多态性已得到深入研究。通过对巴西613份样本的分析，我们发现有证据表明不同的多态性人类白细胞抗原（HLA）基因参与了HPV感染的清除和维持。此外，纯合子密码子72 p53-Arg基因等位基因与HPV相关宫颈癌发生的易感性有关。然而，不同人群中已报道了支持和反对的数据。因此，需要开展国际合作研究来确定所描述关联的一致性。
