Fadyukova Olga E, Storozhevykh Tatiana P, Pinelis Vsevolod G, Koshelev Vladimir B
Faculty of Medicine, Lomonosov Moscow State University, Lomonosovsky Pr., 31/5 Moscow 117192, Russia.
Brain Res. 2004 Jan 2;995(1):145-9. doi: 10.1016/j.brainres.2003.09.062.
In our study, we examined middle cerebral artery (MCA) contractile responses in two animal models. After hemorrhagic disturbances in rats of Krushinsky-Molodkina strain (KMRs) a decrease in contractile responses to serotonin (5-HT) was observed. During incomplete global cerebral ischemia, MCAs had increased responsiveness to endothelin-1 (ET-1), but reduced responsiveness to serotonin. These findings suggest that cerebral circulation disorders alter cerebrovascular function possibly leading to secondary disturbances in brain circulation.
在我们的研究中，我们在两种动物模型中检测了大脑中动脉（MCA）的收缩反应。在克鲁申斯基-莫洛迪纳品系大鼠（KMRs）出现出血性紊乱后，观察到对血清素（5-HT）的收缩反应降低。在不完全性全脑缺血期间，大脑中动脉对内皮素-1（ET-1）的反应性增加，但对血清素的反应性降低。这些发现表明，脑循环障碍会改变脑血管功能，可能导致脑循环的继发性紊乱。
