Fadiukova O E, Storozhevykh T P, Pinelis V G, Koshelev V B
Moscow State University, Vorobyevy Gory, Russia.
Ross Fiziol Zh Im I M Sechenova. 1998 Jul;84(7):672-8.
Reactivity of the middle cerebral artery (MCA) to serotonin was attenuated in vitro in vessels taken from rats following an audiogenic stress. The MCA reactivity to endothelin remained unchanged. Chronic cerebral ischemia diminished the 5-HT-induced contraction and the contractile responses to endothelin were enhanced. Preliminary hypoxic adaptation decreased the artery sensitivity to endothelin in ischemic animals. The findings suggest that a progressing ischemia may involve changes in reactivity of cerebral vessels whereupon hypoxic adaptation may prove to be protecting the brain from ischemia development.
在接受听源性应激的大鼠所取血管中，大脑中动脉（MCA）对5-羟色胺的反应性在体外减弱。MCA对内皮素的反应性保持不变。慢性脑缺血减弱了5-羟色胺诱导的收缩，而对内皮素的收缩反应增强。初步的低氧适应降低了缺血动物动脉对内皮素的敏感性。这些发现表明，进行性缺血可能涉及脑血管反应性的变化，而低氧适应可能证明对大脑免受缺血发展具有保护作用。
