Messinis Ioannis E
Department of Obstetrics and Gynaecology, University of Thessalia, Medical School, 22 Papakiriazi Street, 41222 Larissa, Greece.
Ann N Y Acad Sci. 2003 Nov;997:35-41. doi: 10.1196/annals.1290.004.
Ovarian steroids are important regulators of gonadotropin secretion during the normal menstrual cycle. Estradiol is the predominant factor in the follicular phase, while progesterone plays an important role in the luteal phase. Gonadotropin surge attenuating factor (GnSAF) is a nonsteroidal ovarian substance that attenuates the endogenous LH surge in superovulated women. Attempts to purify GnSAF from various sources have provided several sequences. In human follicular fluid, GnSAF is shown to be the carboxyl terminal fragment of human serum albumin (HSA) and a molecular mass of 12.5 kDa. Preliminary data have shown the expression of the carboxyl terminal fragment of HSA in human granulosa cells. In vivo studies have provided evidence that GnSAF may participate in the control of LH response to GnRH in the context of a mechanism that facilitates the full expression of the midcycle LH surge. Further research is expected to clarify the role of GnSAF in women's physiology.
在正常月经周期中，卵巢甾体激素是促性腺激素分泌的重要调节因子。雌二醇是卵泡期的主要因素，而孕酮在黄体期发挥重要作用。促性腺激素激增衰减因子（GnSAF）是一种非甾体类卵巢物质，可减弱超排卵女性的内源性促黄体生成素激增。从各种来源纯化GnSAF的尝试已提供了多个序列。在人卵泡液中，GnSAF被证明是人血清白蛋白（HSA）的羧基末端片段，分子量为12.5 kDa。初步数据显示HSA羧基末端片段在人颗粒细胞中的表达。体内研究已提供证据表明，在促进周期中期促黄体生成素激增充分表达的机制中，GnSAF可能参与对促性腺激素释放激素（GnRH）的促黄体生成素反应的控制。预计进一步的研究将阐明GnSAF在女性生理中的作用。
