细胞周期动力学：关卡、计量器和定时器。
Dynamics of the cell cycle: checkpoints, sizers, and timers.
作者信息
Qu Zhilin, MacLellan W Robb, Weiss James N
机构信息
Cardiovascular Research Laboratory, Departments of Medicine (Cardiology) and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA.
出版信息
Biophys J. 2003 Dec;85(6):3600-11. doi: 10.1016/S0006-3495(03)74778-X.
Abstract
We have developed a generic mathematical model of a cell cycle signaling network in higher eukaryotes that can be used to simulate both the G1/S and G2/M transitions. In our model, the positive feedback facilitated by CDC25 and wee1 causes bistability in cyclin-dependent kinase activity, whereas the negative feedback facilitated by SKP2 or anaphase-promoting-complex turns this bistable behavior into limit cycle behavior. The cell cycle checkpoint is a Hopf bifurcation point. These behaviors are coordinated by growth and division to maintain normal cell cycle and size homeostasis. This model successfully reproduces sizer, timer, and the restriction point features of the eukaryotic cell cycle, in addition to other experimental findings.
摘要
我们构建了一个高等真核生物细胞周期信号网络的通用数学模型，该模型可用于模拟G1/S期和G2/M期转换。在我们的模型中，CDC25和wee1促成的正反馈导致细胞周期蛋白依赖性激酶活性出现双稳态，而SKP2或后期促进复合物促成的负反馈则将这种双稳态行为转变为极限环行为。细胞周期检查点是一个霍普夫分岔点。这些行为通过生长和分裂进行协调，以维持正常的细胞周期和大小稳态。该模型除了能重现其他实验结果外，还成功再现了真核细胞周期的大小调控、时间调控以及限制点特征。
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本文引用的文献
1
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Chaos. 2001 Mar;11(1):84-97. doi: 10.1063/1.1338126.
2
Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2.构建细胞周期振荡器：Cdc2激活过程中的滞后现象和双稳性
Nat Cell Biol. 2003 Apr;5(4):346-51. doi: 10.1038/ncb954.
3
Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts.滞后现象驱动非洲爪蟾卵提取物中的细胞周期转变。
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):975-80. doi: 10.1073/pnas.0235349100. Epub 2002 Dec 30.
4
The dynamics of cell cycle regulation.细胞周期调控的动力学
Bioessays. 2002 Dec;24(12):1095-109. doi: 10.1002/bies.10191.
5
Regulation of the mammalian cell cycle: a model of the G1-to-S transition.哺乳动物细胞周期的调控：G1期到S期转换的模型
Am J Physiol Cell Physiol. 2003 Feb;284(2):C349-64. doi: 10.1152/ajpcell.00066.2002. Epub 2002 Oct 9.
6
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8
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Science. 2001 Oct 5;294(5540):173-7. doi: 10.1126/science.1065203. Epub 2001 Aug 30.
9
Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions.真核细胞周期的调控：分子拮抗、滞后现象及不可逆转变
J Theor Biol. 2001 May 21;210(2):249-63. doi: 10.1006/jtbi.2001.2293.
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J Theor Biol. 2001 May 21;210(2):167-86. doi: 10.1006/jtbi.2000.2294.
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