Baudouin-Cornu Peggy, Schuerer Katja, Marlière Philippe, Thomas Dominique
Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, 91 198 Gif sur Yvette, France.
J Biol Chem. 2004 Feb 13;279(7):5421-8. doi: 10.1074/jbc.M306415200. Epub 2003 Nov 29.
Discerning the significant relations that exist within and among genome sequences is a major step toward the modeling of biopolymer evolution. Here we report the systematic analysis of the atomic composition of proteins encoded by organisms representative of each kingdoms. Protein atomic contents are shown to vary largely among species, the larger variations being observed for the main architectural component of proteins, the carbon atom. These variations apply to the bulk proteins as well as to subsets of ortholog proteins. A pronounced correlation between proteome carbon content and genome base composition is further evidenced, with high G+C genome content being related to low protein carbon content. The generation of random proteomes and the examination of the canonical genetic code provide arguments for the hypothesis that natural selection might have driven genome base composition.
识别基因组序列内部和之间存在的重要关系是迈向生物聚合物进化建模的重要一步。在这里，我们报告了对代表每个王国的生物体所编码蛋白质的原子组成的系统分析。结果表明，蛋白质的原子含量在物种间差异很大，其中蛋白质的主要结构成分碳原子的变化更为明显。这些变化不仅适用于整体蛋白质，也适用于直系同源蛋白质子集。蛋白质组碳含量与基因组碱基组成之间存在显著相关性，高G+C基因组含量与低蛋白质碳含量相关。随机蛋白质组的生成以及对标准遗传密码的研究为自然选择可能驱动基因组碱基组成这一假说提供了依据。
