哺乳动物中鼠白血病病毒限制的特征描述。
Characterization of murine leukemia virus restriction in mammals.
作者信息
Besnier Caroline, Ylinen Laura, Strange Benjamin, Lister Adrian, Takeuchi Yasuhiro, Goff Stephen P, Towers Greg J
机构信息
Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF, United Kingdom.
出版信息
J Virol. 2003 Dec;77(24):13403-6. doi: 10.1128/jvi.77.24.13403-13406.2003.
Abstract
Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked.
摘要
在一系列哺乳动物的细胞中检测了对鼠白血病病毒（MLV）的限制作用。所有非鼠类的限制都是对N-嗜性MLV感染的饱和阻断，其中一些发生在逆转录之前。我们证明了蝙蝠细胞中的限制作用，并表明如果我们在人类细胞中表达鼠类限制因子Fv1，那么定义感染被阻断阶段的是Fv1，而非人类宿主。
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