咳嗽。3：慢性咳嗽与胃食管反流。
Cough. 3: chronic cough and gastro-oesophageal reflux.
作者信息
Fontana G A, Pistolesi M
机构信息
Dipartimento di Area Critica Medico Chirurgica, Sezione di Medicina Respiratoria, Università di Firenze, Viale G B Morgani, 85 50134 Firenze, Italy.
出版信息
Thorax. 2003 Dec;58(12):1092-5. doi: 10.1136/thorax.58.12.1092.
Abstract
The pathogenesis and clinical features of gastro-oesophageal reflux related cough are complex and the diagnostic tests available are of limited reliability. Treatment needs to be tailored to the specific needs of individual patients and other possible causes of chronic cough should be investigated. Treatment should only be considered to have failed when cough persists after administration of proton pump inhibitors at an adequate dosage for a sufficient length of time.
摘要
胃食管反流相关性咳嗽的发病机制和临床特征较为复杂，现有的诊断测试可靠性有限。治疗需要根据个体患者的具体需求进行调整，并且应调查慢性咳嗽的其他可能病因。只有在给予足够剂量的质子泵抑制剂并持续足够长的时间后咳嗽仍持续存在时，才应认为治疗失败。
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本文引用的文献
1
A clinical test for esophagitis.一项食管炎的临床检测。
Gastroenterology. 1958 May;34(5):760-81.
2
The persistently troublesome cough.持续令人烦恼的咳嗽。
Am J Respir Crit Care Med. 2002 Jun 1;165(11):1469-74. doi: 10.1164/rccm.2110097.
3
Chronic cough due to gastroesophageal reflux disease: failure to resolve despite total/near-total elimination of esophageal acid.胃食管反流病所致慢性咳嗽：尽管食管酸暴露已完全/近乎完全消除，但咳嗽仍未缓解。
Chest. 2002 Apr;121(4):1132-40. doi: 10.1378/chest.121.4.1132.
4
Symptom predictability of reflux-induced respiratory disease.反流性呼吸道疾病的症状可预测性。
Dig Dis Sci. 2002 Jan;47(1):9-14. doi: 10.1023/a:1013290715062.
5
Temporal associations between coughing or wheezing and acid reflux in asthmatics.哮喘患者咳嗽或喘息与胃酸反流之间的时间关联。
Gut. 2001 Dec;49(6):767-72. doi: 10.1136/gut.49.6.767.
6
The clinical meaning of the third heart sound.
Am J Med. 2001 Aug;111(2):157-8. doi: 10.1016/s0002-9343(01)00809-9.
7
Pharyngeal pH measurements in patients with respiratory symptoms before and during proton pump inhibitor therapy.
Am J Surg. 2001 May;181(5):466-70. doi: 10.1016/s0002-9610(01)00597-9.
8
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