Maianski N A, Maianski A N, Kuijpers T W, Roos D
Emma Children's Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Acta Haematol. 2004;111(1-2):56-66. doi: 10.1159/000074486.
Regulation of the neutrophil life span by apoptosis provides a fine balance between their function as effector cells of host defense and a safe turnover of these potentially harmful cells. Alterations of neutrophil apoptosis are associated with a number of diseases. As do other cell types, neutrophils possess components of both extrinsic and intrinsic apoptotic routes. The intrinsic pathway of apoptosis seems to be of major importance in neutrophils since they are programmed for a rapid spontaneous cell death. However, in neutrophils this mechanism of apoptosis has special features, probably due to peculiarities of neutrophil mitochondria, which are believed to be a core regulator of intrinsic cell death. A better understanding of mechanisms underlying neutrophil cell death would help to understand neutrophil physiology and contribute to the search of new approaches for handling of pathology related to disturbances in neutrophil apoptosis and also increase our knowledge of inflammation in general.
通过凋亡调节中性粒细胞的寿命，在其作为宿主防御效应细胞的功能与这些潜在有害细胞的安全更新之间实现了精细平衡。中性粒细胞凋亡的改变与多种疾病相关。与其他细胞类型一样，中性粒细胞同时具备外源性和内源性凋亡途径的成分。凋亡的内源性途径在中性粒细胞中似乎尤为重要，因为它们被设定为快速自发细胞死亡。然而，在中性粒细胞中，这种凋亡机制具有特殊特征，这可能是由于中性粒细胞线粒体的特性所致，线粒体被认为是细胞内源性死亡的核心调节因子。更好地理解中性粒细胞死亡的潜在机制，将有助于理解中性粒细胞生理学，并有助于寻找处理与中性粒细胞凋亡紊乱相关病理的新方法，同时也能增加我们对一般炎症的认识。
