Chen Xin, Chen Bingdi, Zhao Huadong
Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an 710032, China.
The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, China.
Cancers (Basel). 2025 Apr 11;17(8):1298. doi: 10.3390/cancers17081298.
As one of the leading components in the immune system, neutrophils in the tumor microenvironment (TME) have received considerable attention in recent years. The tumor-killing effects of neutrophils in a variety of tumors have been reported. However, the functions of neutrophils in tumors remain to be completely elucidated, and both anti-tumor and tumor-promotion activities have been reported. This review focuses on the characteristics of neutrophils and their mechanisms of action in the TME, with an emphasis on their anti-tumor activity, including reactive oxygen species (ROS)-induced tumor killing, cytotoxic T lymphocytes (CTLs)-induced tumor killing, trogocytosis, cytotoxic enzymes, and trained immunity. Furthermore, the possible targets and methods of tumor treatment regimens for neutrophils are explored, with the aim of exploring the use of neutrophils in the future as a potential anti-tumor treatment strategy.
作为免疫系统的主要组成部分之一，肿瘤微环境（TME）中的中性粒细胞近年来受到了广泛关注。已有报道称中性粒细胞在多种肿瘤中具有杀伤肿瘤的作用。然而，中性粒细胞在肿瘤中的功能仍有待全面阐明，并且既有抗肿瘤活性的报道，也有促进肿瘤生长活性的报道。本综述聚焦于中性粒细胞的特征及其在肿瘤微环境中的作用机制，重点阐述其抗肿瘤活性，包括活性氧（ROS）诱导的肿瘤杀伤、细胞毒性T淋巴细胞（CTL）诱导的肿瘤杀伤、噬细胞作用、细胞毒性酶以及训练免疫。此外，还探讨了针对中性粒细胞的肿瘤治疗方案可能的靶点和方法，旨在探索未来将中性粒细胞用作潜在抗肿瘤治疗策略的可能性。
