National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100091, China.
The Second Department of Gerontology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Oxid Med Cell Longev. 2022 Aug 3;2022:1438470. doi: 10.1155/2022/1438470. eCollection 2022.
Intermittent hypoxia (IH) has a dual nature. On the one hand, chronic IH (CIH) is an important pathologic feature of obstructive sleep apnea (OSA) syndrome (OSAS), and many studies have confirmed that OSA-related CIH (OSA-CIH) has atherogenic effects involving complex and interacting mechanisms. Limited preventive and treatment methods are currently available for this condition. On the other hand, non-OSA-related IH has beneficial or detrimental effects on the body, depending on the degree, duration, and cyclic cycle of hypoxia. It includes two main states: intermittent hypoxia in a simulated plateau environment and intermittent hypoxia in a normobaric environment. In this paper, we compare the two types of IH and summarizes the pathologic mechanisms and research advances in the treatment of OSA-CIH-induced atherosclerosis (AS), to provide evidence for the systematic prevention and treatment of OSAS-related AS.
间歇性低氧（IH）具有双重性质。一方面，慢性间歇性低氧（CIH）是阻塞性睡眠呼吸暂停（OSA）综合征（OSAS）的一个重要病理特征，许多研究证实，与 OSA 相关的 CIH（OSA-CIH）具有致动脉粥样硬化作用，涉及复杂的相互作用机制。目前，对于这种情况，预防和治疗方法有限。另一方面，与 OSA 无关的 IH 对身体有有益或有害的影响，这取决于缺氧的程度、持续时间和周期性循环。它包括两种主要状态：模拟高原环境中的间歇性低氧和常压低氧环境中的间歇性低氧。在本文中，我们比较了这两种类型的 IH，并总结了 OSA-CIH 诱导的动脉粥样硬化（AS）的病理机制和治疗研究进展，为 OSA 相关 AS 的系统预防和治疗提供依据。
