Parker Jane E, Mufti Ghulam J
Department of Haematological Medicine, Norfolk & Norwich University Hospital, Norwich, UK.
Acta Haematol. 2004;111(1-2):78-99. doi: 10.1159/000074488.
Apoptosis is upregulated in early myelodysplastic syndromes (MDS) and may contribute to the peripheral cytopenias commonly observed. Conversely, leukemic progression is associated with abrogation of programmed cell death (PCD). The stage of hematopoietic cell maturation at which defects in PCD arise and the underlying causes of apoptosis dysregulation remain unknown. This paper outlines the apoptotic process in normal hematopoietic cells and summarizes current data regarding the role, potential causes and clinical implications of altered apoptosis in MDS.
凋亡在早期骨髓增生异常综合征（MDS）中上调，可能导致常见的外周血细胞减少。相反，白血病进展与程序性细胞死亡（PCD）的缺失有关。PCD缺陷出现时造血细胞成熟的阶段以及凋亡失调的潜在原因仍不清楚。本文概述了正常造血细胞中的凋亡过程，并总结了关于MDS中凋亡改变的作用、潜在原因及临床意义的现有数据。
