Janssen Luca L G, van Leeuwen-Kerkhoff Nathalie, Westers Theresia M, de Gruijl Tanja D, van de Loosdrecht Arjan A
Department of Hematology, Amsterdam University Medical Center (UMC), Vrije Universiteit, Amsterdam, Netherlands.
Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, Netherlands.
Front Oncol. 2024 Jul 26;14:1414102. doi: 10.3389/fonc.2024.1414102. eCollection 2024.
Myelodysplastic neoplasms (MDS) are clonal disorders of the myeloid lineage leading to peripheral blood cytopenias. Dysregulation of innate immunity is hypothesized to be a potent driver of MDS. A recent study revealed increased thrombomodulin (TM) expression on classical monocytes in MDS, which was associated with prolonged survival. TM is a receptor with immunoregulatory capacities, however, its exact role in MDS development remains to be elucidated. In this review we focus on normal monocyte biology and report on the involvement of monocytes in myeloid disease entities with a special focus on MDS. Furthermore, we delve into the current knowledge on TM and its function in monocytes in health and disease and explore the role of TM-expressing monocytes as driver, supporter or epiphenomenon in the MDS bone marrow environment.
骨髓增生异常肿瘤（MDS）是髓系的克隆性疾病，可导致外周血细胞减少。先天免疫失调被认为是MDS的一个重要驱动因素。最近的一项研究显示，MDS患者经典单核细胞上的血栓调节蛋白（TM）表达增加，这与生存期延长有关。TM是一种具有免疫调节能力的受体，然而，其在MDS发生发展中的确切作用仍有待阐明。在这篇综述中，我们重点关注正常单核细胞生物学，并报告单核细胞在髓系疾病实体中的参与情况，特别关注MDS。此外，我们深入探讨了目前关于TM及其在健康和疾病状态下单核细胞中的功能的知识，并探讨了表达TM的单核细胞在MDS骨髓微环境中作为驱动因素、支持因素或附带现象的作用。
