Kelishadi Roya, Sabet Babak, Khosravi Alireza
Surveillance Unit, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Med Sci Monit. 2003 Dec;9(12):CR515-8.
The objective of our research was to study anticardiolipin antibody (ACLA) in the offspring of families at high risk for premature coronary heart disease (CHD) in comparison to controls, and the degree of agreement between ACLA levels in parents and children.
MATERIAL/METHODS: In an analytical case-control study, three paired parent-child groups of 50 each were selected by simple random sampling, and their IgG ACLA levels measured by ELISA method. A comparison was made between parents who had premature myocardial infarction (MI<55 years of age) and one child aged between 12 to 19 years as the case group, parents with MI>55 years and one child, and parents with no history of heart attacks and one child as the first and second control groups, respectively.
The prevalence of positive ACLA in adolescents in the case group was significantly higher than the second control group (P=0.03), but this difference was not significant against the first control group (p>0.05). Regarding parents, there were significant differences between the case group and both control groups (P=0.04 and P=0.009, respectively). A substantial degree of correlation was found between positive ACLA in patients with premature MI and their children (kappa correlation coefficient =0.63, 95% CI, 0.47-0.79).
The findings of this study point to the probable presence of a familial immunological background in the onset of premature atherosclerosis with regard to ACLA, which can be measured as a risk factor in predicting premature CHD.
我们研究的目的是，与对照组相比，研究冠心病（CHD）早发高危家庭后代中的抗心磷脂抗体（ACLA），以及父母与子女ACLA水平之间的一致性程度。
材料/方法：在一项分析性病例对照研究中，通过简单随机抽样选取了三个配对的亲子组，每组各50对，采用酶联免疫吸附测定（ELISA）法测量其IgG ACLA水平。将患有早发心肌梗死（MI<55岁）的父母及其一名12至19岁的子女作为病例组，将MI>55岁的父母及其一名子女，以及无心脏病发作史的父母及其一名子女分别作为第一和第二对照组进行比较。
病例组青少年中ACLA阳性的患病率显著高于第二对照组（P = 0.03），但与第一对照组相比，这一差异不显著（p>0.05）。关于父母，病例组与两个对照组之间均存在显著差异（分别为P = 0.04和P = 0.009）。早发MI患者及其子女的ACLA阳性之间存在高度相关性（kappa相关系数=0.63，95%CI，0.47 - 0.79）。
本研究结果表明，就ACLA而言，早发动脉粥样硬化发病可能存在家族免疫背景，ACLA可作为预测早发CHD的一个危险因素进行检测。
