Mihai K, Jancsó T
Bács-Kiskun Megyei Tanács, Hollós József Kórház-Rendelöintézet, Kecskemét, I. Belgyógyászati Osztály.
Orv Hetil. 1991 Aug 25;132(34):1861-3.
140 children of parents who had acute myocardial infarction before age 45 and 75 healthy children without any familial history of coronary artery disease--as a control group--were investigated ranging in age from 3-18 years. It was found that plasma fibrinogen concentration significantly increased compared to age and sex adjusted control in sons of parents suffering from premature coronary artery disease. Results of this study suggest a significant association between parents' and children's fibrinogen level. It may be concluded from this study that the fibrinogen is a definitive marker for identifying risk children's. Preventive strategies in childhood should consider the role of this genetic factor in later manifestation of coronary artery disease and it would be necessary to emphasize the importance of eliminating environmental influences and change life-style in exposed families.
对140名父母在45岁之前患有急性心肌梗死的儿童以及75名无任何冠心病家族史的健康儿童（作为对照组）进行了调查，这些儿童年龄在3至18岁之间。研究发现，与年龄和性别调整后的对照组相比，患有早发性冠心病父母的儿子血浆纤维蛋白原浓度显著升高。本研究结果表明父母与子女的纤维蛋白原水平之间存在显著关联。从这项研究可以得出结论，纤维蛋白原是识别高危儿童的一个决定性标志物。儿童期的预防策略应考虑到这一遗传因素在冠心病后期表现中的作用，并且有必要强调消除环境影响和改变暴露家庭生活方式的重要性。
