Akimova E V
Laboratory of Medical Genetics, Ukrainian Children & Adolescents Health Care Institute, Kharkov.
Coron Artery Dis. 1994 Sep;5(9):761-5.
The aim of this study was to trace the possible mechanisms of premature atherosclerosis in its early stages and to expand our knowledge of the genetic structure of an inherited predisposition to coronary heart disease (CHD) by monitoring of TXA2 and PGI2 levels in the children of fathers who have suffered a premature myocardial infarction.
Prostacyclin (PGI2) and thromboxane A2 (TXA2) levels were estimated by radioimmunoassay in 90 children (aged 7-18 years) of fathers who had suffered premature infarction and in both their parents (the 'main' group, n = 191), and in 59 of their healthy contemporaries with no family history of ischaemic events, hypertension, or diabetes, and both their parents (the 'control' group, n = 110).
Sons of early infarction patients presented an average TXA2 level of 158.94 +/- 16.60 pg/ml (versus 86.88 +/- 12.71 pg/ml in the control group, P < 0.001), and daughters presented an average TXA2 level of 230.13 +/- 33.68 pg/ml (versus 69.67 +/- 14.99 pg/ml in the control group, P < 0.001). This hyperproduction was independent of the children's sex and could not be attributed to health problems. A significant increase (two-fold) of PGI2 in the boys but not in the girls of the main group was noted. Daughters of infarction patients had significantly higher levels of TXA2 than PGI2. The wives of early infarction patients presented a significantly higher level of both TXA2 and PGI2 (two and three times the level in the control group, P < 0.02 and P < 0.05, respectively).
Spontaneous TXA2 hyperproduction is intrinsic among children with an inherited propensity for CHD and is strongly determined by genetic factors, which is evident from the structure of in-family phenotypic correlations of PGI2 and TXA2 levels.
本研究的目的是通过监测患有过早心肌梗死的父亲的子女的血栓素A2（TXA2）和前列环素（PGI2）水平，探寻动脉粥样硬化早期阶段的可能机制，并拓展我们对冠心病（CHD）遗传易感性基因结构的认识。
采用放射免疫分析法对90名患有过早梗死的父亲的子女（年龄7 - 18岁）及其父母（“主要”组，n = 191），以及59名无缺血性事件、高血压或糖尿病家族史的健康同龄人及其父母（“对照组”，n = 110）的前列环素（PGI2）和血栓素A2（TXA2）水平进行了评估。
早期梗死患者的儿子的TXA2平均水平为158.94 ± 16.60 pg/ml（对照组为86.88 ± 12.71 pg/ml，P < 0.001），女儿的TXA2平均水平为230.13 ± 33.68 pg/ml（对照组为69.67 ± 14.99 pg/ml，P < 0.001）。这种高产生与孩子的性别无关，也不能归因于健康问题。主要组的男孩中PGI2显著增加（两倍），而女孩中未出现这种情况。梗死患者的女儿的TXA2水平显著高于PGI2。早期梗死患者的妻子的TXA2和PGI2水平均显著较高（分别是对照组水平的两倍和三倍，P < 0.02和P < 0.05）。
自发的TXA2高产生是具有CHD遗传倾向的儿童的内在特征，并且由遗传因素强烈决定，这从PGI2和TXA2水平的家族内表型相关性结构中可以明显看出。
