Matthews Jacqueline M, Visvader Jane E
School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia.
EMBO Rep. 2003 Dec;4(12):1132-7. doi: 10.1038/sj.embor.7400030.
The ubiquitous nuclear adaptor protein LIM-domain-binding protein 1 (Ldb1) was originally identified as a cofactor for LIM-homeodomain and LIM-only (LMO) proteins that have fundamental roles in development. In parallel, Ldb1 has been shown to have essential functions in diverse biological processes in different organisms. The recent targeting of this gene in mice has revealed roles for Ldb1 in neural patterning and development that have been conserved throughout evolution. Furthermore, the elucidation of the three-dimensional structures of LIM-Ldb1 complexes has provided insight into the molecular basis for the ability of Ldb1 to contact diverse LIM-domain proteins. It has become evident that Ldb1 is a multi-adaptor protein that mediates interactions between different classes of transcription factors and their co-regulators and that the nature of these complexes determines cell fate and differentiation.
普遍存在的核衔接蛋白LIM结构域结合蛋白1（Ldb1）最初被鉴定为LIM同源结构域蛋白和仅含LIM（LMO）蛋白的辅助因子，这些蛋白在发育过程中具有重要作用。与此同时，Ldb1已被证明在不同生物体的多种生物过程中具有关键功能。最近在小鼠中对该基因的靶向研究揭示了Ldb1在神经模式形成和发育中的作用，这些作用在整个进化过程中都得到了保留。此外，对LIM-Ldb1复合物三维结构的阐明为Ldb1与多种LIM结构域蛋白接触的分子基础提供了见解。很明显，Ldb1是一种多衔接蛋白，介导不同类别的转录因子与其共调节因子之间的相互作用，并且这些复合物的性质决定了细胞命运和分化。
