日本成年造血干细胞移植后迟发性出血性膀胱炎患者中男性居多。
Male predominance among Japanese adult patients with late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation.
作者信息
Asano Y, Kanda Y, Ogawa N, Sakata-Yanagimoto M, Nakagawa M, Kawazu M, Goyama S, Kandabashi K, Izutsu K, Imai Y, Hangaishi A, Kurokawa M, Tsujino S, Ogawa S, Aoki K, Chiba S, Motokura T, Hirai H
机构信息
Department of Cell Therapy & Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan.
出版信息
Bone Marrow Transplant. 2003 Dec;32(12):1175-9. doi: 10.1038/sj.bmt.1704274.
Late-onset hemorrhagic cystitis (LHC) after hematopoietic stem cell transplantation (HSCT) is mainly caused by viral infections. We retrospectively analyzed the records of 141 Japanese adult patients who underwent a first allogeneic HSCT from 1995 to 2002. In all, 19 patients developed LHC a median of 51 days after HSCT. Adenovirus (AdV) was detected in the urine of 10 LHC patients, of whom eight had AdV type 11. Five of the six available serum samples from these patients were also positive for AdV type 11, but the detection of AdV in serum was not associated with a worse outcome. Male sex and the development of grade II-IV acute graft-versus-host disease were identified as independent significant risk factors for LHC. Male predominance was detected in LHC after HSCT, as has been previously shown in children with AdV-induced acute HC. The detection of AdV DNA in serum did not predict a poor outcome.
造血干细胞移植（HSCT）后迟发性出血性膀胱炎（LHC）主要由病毒感染引起。我们回顾性分析了1995年至2002年间接受首次异基因HSCT的141例日本成年患者的记录。总共有19例患者在HSCT后中位51天发生LHC。在10例LHC患者的尿液中检测到腺病毒（AdV），其中8例为11型AdV。这些患者6份可用血清样本中的5份11型AdV也呈阳性，但血清中AdV的检测与较差的预后无关。男性以及II-IV级急性移植物抗宿主病的发生被确定为LHC的独立显著危险因素。HSCT后LHC中检测到男性占主导，正如先前在AdV诱导的急性出血性膀胱炎儿童中所显示的那样。血清中AdV DNA的检测不能预测不良预后。
Zotero 插件