Bogdanovic G, Ljungman P, Wang F, Dalianis T
Institute for Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Sweden.
Bone Marrow Transplant. 1996 Apr;17(4):573-6.
In BMT patients, shedding of BK virus (BKV) in the urine has been strongly but not absolutely correlated to hemorrhagic cystitis (HC). The possible presence of human polyomaviruses in peripheral blood leukocytes (PBLs), plasma, serum and urine in BMT patients and an association with HC was investigated by a nested PCR assay. Samples from allogeneic BMT patients with and without HC as well as from autologous BMT patients were analyzed. Human polyomaviruses were detected in urine and blood samples of both allogeneic and autologous BMT patients with and without HC. An association between the presence of a specific human polyomavirus in blood and HC was thus not observed.
在骨髓移植（BMT）患者中，尿液中BK病毒（BKV）的排出与出血性膀胱炎（HC）有很强但并非绝对的相关性。通过巢式聚合酶链反应（PCR）检测法，对BMT患者外周血白细胞（PBL）、血浆、血清和尿液中人类多瘤病毒的可能存在情况及其与HC的关联进行了研究。分析了来自有或无HC的异基因BMT患者以及自体BMT患者的样本。在有或无HC的异基因和自体BMT患者的尿液和血液样本中均检测到了人类多瘤病毒。因此，未观察到血液中特定人类多瘤病毒的存在与HC之间存在关联。
