Yamane K, Miyauchi T, Suzuki N, Yuhara T, Akama T, Suzuki H, Kashiwagi H
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
J Rheumatol. 1992 Oct;19(10):1566-71.
Endothelin-1 (ET-1) is a novel potent vasoconstrictor peptide discovered in the supernatant fraction of cultured endothelial cells. We measured plasma levels of ET-1 using a sensitive sandwich enzyme immunoassay. Plasma concentrations of ET-1 in 31 patients with systemic sclerosis (SSc) (1.90 +/- 0.47 pg/ml) were higher than those (1.31 +/- 0.10 pg/ml) in 25 age and sex matched healthy subjects. Patients with SSc with diffuse scleroderma had higher levels of ET-1 compared with those with limited scleroderma. Plasma ET-1 levels correlated inversely with carbon monoxide diffusing capacity (DLco). Measurement of plasma ET-1 levels may be useful as a predictor of prognosis of SSc.
内皮素-1（ET-1）是在培养的内皮细胞上清液中发现的一种新型强效血管收缩肽。我们使用灵敏的夹心酶免疫测定法测量了血浆中ET-1的水平。31例系统性硬化症（SSc）患者的血浆ET-1浓度（1.90±0.47 pg/ml）高于25例年龄和性别匹配的健康受试者（1.31±0.10 pg/ml）。弥漫性硬皮病的SSc患者的ET-1水平高于局限性硬皮病患者。血浆ET-1水平与一氧化碳弥散量（DLco）呈负相关。测量血浆ET-1水平可能有助于预测SSc的预后。
