风湿病学家进行的滑膜组织活检采集：准备好临床应用了吗？
Synovial Tissue Biopsy Collection by Rheumatologists: Ready for Clinical Implementation?
作者信息
Smits Marijn, van de Groes Sebastiaan, Thurlings Rogier M
机构信息
Department of Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands.
Department of Orthopedic Surgery, Radboud University Medical Center, Nijmegen, Netherlands.
出版信息
Front Med (Lausanne). 2019 Jun 20;6:138. doi: 10.3389/fmed.2019.00138. eCollection 2019.
Synovial tissue from arthritis patients is increasingly used for both basic pathophysiological and clinical translational research. This development has been spurred by the development of biotechnological techniques for analysis of complex tissues and the validation of ultrasound guided biopsies for easier tissue sampling. This increasing use of synovial tissue raises questions on standardization of methodologies for tissue processing and cellular & molecular analyses. Furthermore, it raises the question if synovial tissue biopsy analysis may be more widely implemented in clinical practice, what are the methodological hurdles for implementation and what are the lessons that can be learned from previous experience. This will be the focus of this review.
来自关节炎患者的滑膜组织越来越多地用于基础病理生理学和临床转化研究。生物技术用于复杂组织分析的技术发展以及超声引导活检用于更便捷组织采样的验证推动了这一发展。滑膜组织使用的增加引发了关于组织处理以及细胞和分子分析方法标准化的问题。此外，它还引发了一个问题，即滑膜组织活检分析是否可以在临床实践中更广泛地应用，实施的方法障碍是什么，以及可以从以往经验中学到什么教训。这将是本综述的重点。
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