Ohno O, Tateishi H, Cooke T D
Arthritis Rheum. 1978 Jan-Feb;21(1):81-91. doi: 10.1002/art.1780210114.
The earliest and most severe changes in articular collagenous tissues (ACT) occur within 24 hours of antigen challenge and are associated with and are possibly secondary to maximal immune complex deposition in ACT surfaces. The immuno-electron microscopic (immuno-em) staining characterizes the ferritin as aggregates with antibody and suggests its occurrence and deposition as a preformed immune complex. These data indicate a direct interaction between immune complexes and collagenous matrix which could relate to both antigen persistence and chronicity of the immune response. The changes described in this model have features in common with rheumatoid disease and suggest the potential for similar mechanisms of cartilage degradation.
关节胶原组织（ACT）最早且最严重的变化发生在抗原攻击后的24小时内，与ACT表面最大程度的免疫复合物沉积相关，并且可能是其继发结果。免疫电子显微镜（immuno-em）染色将铁蛋白表征为与抗体的聚集体，并提示其作为预先形成的免疫复合物的出现和沉积。这些数据表明免疫复合物与胶原基质之间存在直接相互作用，这可能与抗原持续性和免疫反应的慢性有关。该模型中描述的变化与类风湿性疾病具有共同特征，并提示软骨降解的类似机制的可能性。
