Hwang Wei-Ting, Brookmeyer Ron
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 628 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA.
Lifetime Data Anal. 2003 Sep;9(3):261-74. doi: 10.1023/a:1025884719728.
A panel study consists of individuals who have data collected at periodic follow-up visits or pre-specified time points following entry into the study. The objective of this paper is to consider design issues in a panel study when the response variable is the stage of disease, and with focus on the transition intensities. Important design issues include the choice of the time interval between follow-up visits and sample size considerations. We study the effects of time intervals between follow-up visits on the precision of the transition intensities estimators. We also consider the power of statistical tests on the ratio of transition intensities. Discussion is extended to incorporate heterogeneity in the population in which frailty is introduced to describe subject-specific transition intensities.
一项面板研究由在进入研究后定期随访或预先指定时间点收集数据的个体组成。本文的目的是在响应变量为疾病阶段且重点关注转移强度的情况下，考虑面板研究中的设计问题。重要的设计问题包括随访之间时间间隔的选择和样本量的考虑。我们研究随访之间时间间隔对转移强度估计精度的影响。我们还考虑了关于转移强度比率的统计检验的功效。讨论扩展到纳入人群中的异质性，其中引入脆弱性来描述个体特定的转移强度。
