Guebre-Egziabher F, Fouque D
Département de néphrologie, Centre de recherche en nutrition humaine, Hôpital Edouard Herriot, Lyon.
Nephrologie. 2003;24(7):383-6.
Chronic inflammation is very common in patients on maintenance dialysis. It is associated with an increase of many cytokines (especially: IL-1, IL-6 and TNF alpha). This inflammation leads to hormonal dysregulation (leptin, adiponectin, insulin). Increase in cytokines is associated with a high cardio-vascular morbi-mortality for general population as well as for uremic patients. Many metabolic abnormalities are due to chronic inflammation: protein catabolism, anorexia and many others. Among them, the "metabolic" syndrome includes adiposis, dyslipemia, insulinoresistance and high blood pressure very often present in chronic uremic patients. It is still unknown whether anti-inflammatory treatments would improve inflammation consequences in dialysis.
慢性炎症在维持性透析患者中非常常见。它与多种细胞因子（尤其是白细胞介素-1、白细胞介素-6和肿瘤坏死因子α）的增加有关。这种炎症会导致激素失调（瘦素、脂联素、胰岛素）。细胞因子的增加与普通人群以及尿毒症患者的高心血管病死亡率相关。许多代谢异常是由慢性炎症引起的：蛋白质分解代谢、厌食等等。其中，“代谢”综合征包括肥胖、血脂异常、胰岛素抵抗和高血压，这些在慢性尿毒症患者中很常见。目前尚不清楚抗炎治疗是否会改善透析中的炎症后果。
