Oner-Iyidogan Yildiz, Oner Pernur, Kocak Hikmet, Gurdol Figen, Bekpinar Seldag, Unlucerci Yesim, Caliskan Yasar, Cetinalp-Demircan Pinar, Kocak Taner, Turkmen Aydin
Medical Laboratory Programme, Medical Services Training School, Istanbul University, Cerrahpasa, Istanbul, Turkey.
Clin Exp Med. 2009 Sep;9(3):235-41. doi: 10.1007/s10238-009-0035-3. Epub 2009 Feb 24.
The aim of this study was to investigate the pro-oxidant and proinflammatory biomarkers and their relationship with dimethylarginines (DMAs) in patients at various stages of chronic kidney disease (CKD). We studied 114 CKD patients, 36 were hemodialyzed, 41 peritoneal dialyzed and 37 nondialyzed (early stage) CKD patients. The control group consisted of 31 healthy subjects. Plasma levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), L-arginine, nitric oxide (NO) and proinflammatory cytokines (TNF-alpha and IL-6) were determined, and their relationships with the degree of disease were evaluated. Both DMAs were at high levels in all CKD patients, whereas arginine concentrations were low in patients undergoing dialysis. Elevated TNF-alpha and IL-6 in CKD patients were indicative of ongoing chronic inflammatory state. A significant positive correlation between SDMA and creatinine suggests that plasma SDMA level may be an index for renal function.
本研究旨在调查慢性肾脏病（CKD）各阶段患者的促氧化剂和促炎生物标志物及其与二甲基精氨酸（DMAs）的关系。我们研究了114例CKD患者，其中36例接受血液透析，41例接受腹膜透析，37例未透析（早期）CKD患者。对照组由31名健康受试者组成。测定了血浆不对称二甲基精氨酸（ADMA）、对称二甲基精氨酸（SDMA）、L-精氨酸、一氧化氮（NO）和促炎细胞因子（TNF-α和IL-6）的水平，并评估了它们与疾病程度的关系。所有CKD患者的两种DMAs水平均较高，而接受透析的患者精氨酸浓度较低。CKD患者中TNF-α和IL-6升高表明存在持续的慢性炎症状态。SDMA与肌酐之间存在显著正相关，提示血浆SDMA水平可能是肾功能的一个指标。
