Rysz Jacek, Banach Maciej, Cialkowska-Rysz Aleksandra, Stolarek Robert, Barylski Marcin, Drozdz Jaroslaw, Okonski Piotr
The 2nd Department of Family Medicine, University Hospital No.2 in Lodz, Medical University in Lodz, Poland.
Cell Mol Immunol. 2006 Apr;3(2):151-4.
Cytokines are essential mediators of immune response and inflammatory reactions. Patients with chronic renal failure (CRF) commonly present with abnormalities of immune function related with impaired kidney function and the accumulation of uremic toxins in addition to bioincompatibility of dialyzer membranes. During a hemodialysis (HD) session, cytokines are released mainly by monocytes activated by endotoxin-type compounds in dialyzer fluid, complement factors and direct contact with dialyzer membrane. The study included 15 CRF patients, aged 36.4 +/- 2.9 years, on regular HD maintenance therapy for mean 68 +/- 10 months and 15 healthy controls. It was designed to assess serum levels of a panel of inflammatory cytokines: IL-1beta, IL-2, IL-6, IL-8 and TNF-alpha in CRF patients on regular maintenance HD before, 20, 60 and 240 minutes of a single HD session in parallel with C-reactive protein (CRP) as an additional parameter. CRP concentration was increased in HD patients when compared with healthy controls. The concentrations of IL-1, IL-6, IL-8 and TNF-alpha were increased, whereas the serum level of IL-2 was not altered during a single HD session.
细胞因子是免疫反应和炎症反应的重要介质。慢性肾衰竭（CRF）患者除透析器膜生物不相容性外，通常还存在与肾功能受损及尿毒症毒素蓄积相关的免疫功能异常。在血液透析（HD）过程中，细胞因子主要由透析液中内毒素样化合物激活的单核细胞、补体因子以及与透析器膜的直接接触释放。该研究纳入了15例CRF患者，年龄为36.4±2.9岁，接受规律HD维持治疗平均68±10个月，以及15名健康对照者。研究旨在评估一组炎症细胞因子：IL-1β、IL-2、IL-6、IL-8和TNF-α在规律维持性HD的CRF患者单次HD治疗前、20分钟、60分钟和240分钟时的血清水平，并将C反应蛋白（CRP）作为附加参数进行平行检测。与健康对照者相比，HD患者的CRP浓度升高。在单次HD治疗期间，IL-1、IL-6、IL-8和TNF-α的浓度升高，而IL-2的血清水平未发生改变。
