印度西部I型自身免疫性肝炎中的HLA基因分型

HLA genotyping in type-I autoimmune hepatitis in Western India.

作者信息

Amarapurkar D N, Patel N D, Amarapurkar Anjali D, Kankonkar S R

机构信息

Department of Gastroenterology, Bombay Hospital and Medical Research Center, Mumbai.

出版信息

J Assoc Physicians India. 2003 Oct;51:967-9.

PMID:14719586

Abstract

OBJECTIVES

To analyze association of different HLA genotypes for predisposition to type-I autoimmune hepatitis in Western India.

METHODS

This study was undertaken on patients of type-I autoimmune hepatitis (defined by international criteria by IAHG, 1999). HLA genotyping for class I and II was done in 20 patients of autoimmune hepatitis and 100 healthy controls. Statistics were done using Halden's modification of Woolfs formula.

RESULT

Significant association of autoimmune hepatitis was found amongst class I antigens--HLA B27 [20 vs. 0 %] & HLA cw4 [40 vs. 15 %] and amongst class II antigens--DRBI01XX [25 vs. 2%], DRB114XX [30 vs. 12%], DRB115XX [40 vs. 25%] and DRB107XX [20 vs. 9 %] at DRB1 locus. Stronger association was found with HLA B27, cw4 & HLA DRB1 *01XX.

CONCLUSION

Our data indicate that predisposition to autoimmune hepatitis is different in Indian patients and not associated with HLA DRB1*03XX or *04XX, as seen in Western world.

摘要

目的

分析印度西部不同HLA基因型与I型自身免疫性肝炎易感性的关联。

方法

本研究针对I型自身免疫性肝炎患者（根据国际自身免疫性肝炎小组（IAHG）1999年的国际标准定义）开展。对20例自身免疫性肝炎患者和100名健康对照进行了I类和II类HLA基因分型。使用哈尔登对伍尔夫公式的修正进行统计学分析。

结果

在I类抗原中发现自身免疫性肝炎与HLA B27[20%对0%]和HLA cw4[40%对15%]显著相关，在II类抗原中与DRBI01XX[25%对2%]、DRB114XX[30%对12%]、DRB115XX[40%对25%]和DRB107XX[20%对9%]在DRB1位点显著相关。发现与HLA B27、cw4和HLA DRB1*01XX的关联更强。