Near S L, Whalen L R, Miller J A, Ishii D N
Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523.
Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11716-20. doi: 10.1073/pnas.89.24.11716.
Injury to mammalian motor nerves can lead to paralysis, but relatively successful regeneration may occur when conditions are favorable. Elucidation of the mechanism upholding successful regeneration is of theoretical and clinical interest. In this study, the hypothesis that insulin-like growth factor II (IGF-II) can stimulate motor nerve regeneration was tested. When IGF-II was infused continuously near a site of crush on the sciatic nerve, the distance of motor axon regeneration was increased significantly in rats. In contrast, spontaneous regeneration was inhibited when an anti-IGF-II antiserum was infused through a "window" in the epineurium. Thus, infused IGF-II can increase, and endogenous IGFs can support, the regeneration of motor axons in lesioned nerves.
哺乳动物运动神经损伤可导致瘫痪，但在条件有利时可能会出现相对成功的再生。阐明支持成功再生的机制具有理论和临床意义。在本研究中，对胰岛素样生长因子II（IGF-II）可刺激运动神经再生这一假说进行了验证。当在大鼠坐骨神经挤压部位附近持续注入IGF-II时，运动轴突再生的距离显著增加。相反，当通过神经外膜上的“窗口”注入抗IGF-II抗血清时，自发再生受到抑制。因此，注入的IGF-II可促进，内源性IGF可支持损伤神经中运动轴突的再生。
