阿片类药物痛觉过敏和耐受性与5-羟色胺1A受体介导的反向耐受性
Opioid hyperalgesia and tolerance versus 5-HT1A receptor-mediated inverse tolerance.
作者信息
Xu Xiao-Jun, Colpaert Francis, Wiesenfeld-Hallin Zsuzsanna
机构信息
Department of Laboratory Medicine, Division of Clinical Neurophysiology, Karolinska Institutet, Huddinge University Hospital, S-141 86, Stockholm, Sweden.
出版信息
Trends Pharmacol Sci. 2003 Dec;24(12):634-9. doi: 10.1016/j.tips.2003.10.005.
In addition to analgesia, opioids also produce paradoxical hyperalgesic effects following acute and chronic treatment. In this article, we review the occurrence of this hyperalgesia under several conditions, and discuss the potential mechanisms and clinical implications. We also review recent evidence that paradoxical analgesia and inverse tolerance induced by stimulation of 5-HT(1A) receptors, which is a mirror image of opioid-induced hyperalgesia and tolerance, might achieve clinically significant analgesia in chronic pain.
除了镇痛作用外，阿片类药物在急性和慢性给药后还会产生反常性痛觉过敏效应。在本文中，我们综述了在几种情况下这种痛觉过敏的发生情况，并讨论了其潜在机制和临床意义。我们还综述了近期的证据，即刺激5-HT(1A)受体诱导的反常性镇痛和反向耐受，这是阿片类药物诱导的痛觉过敏和耐受的镜像，可能在慢性疼痛中实现具有临床意义的镇痛效果。
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