Offit Paul A, Jew Rita K
Division of Infectious Diseases, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, and Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104, USA.
Pediatrics. 2003 Dec;112(6 Pt 1):1394-7. doi: 10.1542/peds.112.6.1394.
Vaccines often contain preservatives, adjuvants, additives, or manufacturing residuals in addition to pathogen-specific immunogens. Some parents, alerted by stories in the news media or information contained on the World Wide Web, are concerned that some of the substances contained in vaccines might harm their children. We reviewed data on thimerosal, aluminum, gelatin, human serum albumin, formaldehyde, antibiotics, egg proteins, and yeast proteins. Both gelatin and egg proteins are contained in vaccines in quantities sufficient to induce rare instances of severe, immediate-type hypersensitivity reactions. However, quantities of mercury, aluminum, formaldehyde, human serum albumin, antibiotics, and yeast proteins in vaccines have not been found to be harmful in humans or experimental animals.
除了病原体特异性免疫原外，疫苗通常还含有防腐剂、佐剂、添加剂或生产残余物。一些家长因新闻媒体报道或万维网上的信息而警觉，担心疫苗中含有的某些物质可能会伤害他们的孩子。我们审查了有关硫柳汞、铝、明胶、人血清白蛋白、甲醛、抗生素、鸡蛋蛋白和酵母蛋白的数据。明胶和鸡蛋蛋白在疫苗中的含量足以引发罕见的严重速发型过敏反应。然而，尚未发现疫苗中的汞、铝、甲醛、人血清白蛋白、抗生素和酵母蛋白的含量对人类或实验动物有害。
