Hall E J, Carter S D, Barnes A, Batt R M
Department of Veterinary Pathology, University of Liverpool.
Res Vet Sci. 1992 Nov;53(3):293-9. doi: 10.1016/0034-5288(92)90129-p.
This study examined whether increased intestinal permeability in Irish setters with gluten-sensitive enteropathy was associated with altered immune responses to ingested antigens, and whether a humoral immune response to gluten is involved in the pathogenesis of the condition. Affected setters reared on a wheat-containing diet were compared with littermates reared on a cereal-free diet and age-matched control setters. Measurement of serum immunoglobulins revealed increased serum IgA concentrations in affected dogs. Antibody responses to a variety of dietary antigens were measured by ELISA. Antibody levels to ovalbumin, collagen I and II and soya were not significantly different from normal dogs. Anti-gliadin antibody concentrations were lower in affected dogs than controls, and correlated with immune complex formation as assessed by C1q binding. The study suggested a modified immune response in dogs with increased intestinal permeability, although there was no major systemic antibody response to dietary antigens.
本研究调查了患有麸质敏感性肠病的爱尔兰雪达犬肠道通透性增加是否与对摄入抗原的免疫反应改变有关，以及对麸质的体液免疫反应是否参与该病症的发病机制。将以含小麦饮食饲养的患病雪达犬与以无谷物饮食饲养的同窝仔犬及年龄匹配的对照雪达犬进行比较。血清免疫球蛋白测量显示患病犬血清IgA浓度升高。通过酶联免疫吸附测定法（ELISA）测量对多种饮食抗原的抗体反应。对卵清蛋白、I型和II型胶原蛋白及大豆的抗体水平与正常犬无显著差异。患病犬的抗麦醇溶蛋白抗体浓度低于对照组，且与通过C1q结合评估的免疫复合物形成相关。该研究表明肠道通透性增加的犬存在免疫反应改变，尽管对饮食抗原没有主要的全身性抗体反应。
