用于1-氨基二烯狄尔斯-阿尔德反应的新型高效手性助剂的设计
Design of a new and highly effective chiral auxiliary for Diels-Alder reaction of 1-aminodiene.
作者信息
Robiette Raphaël, Cheboub-Benchaba Karima, Peeters Daniel, Marchand-Brynaert Jaqueline
机构信息
Unité de Chimie organique et médicinale, Université catholique de Louvain, Place L. Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.
出版信息
J Org Chem. 2003 Dec 12;68(25):9809-12. doi: 10.1021/jo0302049.
PMID:14656111
Abstract
A theoretical investigation of the facial selectivity of optically active oxazolidin-2-one-substituted dienes has been realized. This analysis enabled the development of (R)-4-phenyloxazolidin-2-thione as a very effective chiral auxiliary for cycloaddition of 1-aminodiene.
摘要
已实现了对光学活性恶唑烷-2-酮取代二烯的面选择性进行理论研究。该分析使得能够开发出(R)-4-苯基恶唑烷-2-硫酮作为用于1-氨基二烯环加成反应的一种非常有效的手性助剂。
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