Nettis E, Colanardi M C, Ferrannini A, Tursi A
Department of Medical Clinic, Immunology and Infectious Diseases, Section of Allergy And Clinical Immunology, University of Bari, Bari, Italy.
Clin Exp Allergy. 2003 Dec;33(12):1725-9. doi: 10.1111/j.1365-2222.2003.01825.x.
Tartrazine has been frequently linked to several diseases. However, a cause-and-effect role for tartrazine in these illnesses, especially in urticaria, has not always been established.
The aim of this study is to determine the incidence of intolerance to tartrazine among subjects who experienced an acute episode of urticaria/angioedema following the ingestion of a meal or a product containing this substance.
This was a retrospective study based on analysis of data of patients reported to have experienced episodes of urticaria and/or angioedema after ingesting meals or products containing tartrazine. At the first visit to the outpatients clinic, a careful anamnesis had been taken. Patients had then been submitted to the following diagnostic tests: IgE tests to common inhalant allergens and food allergens and a double-blind placebo-controlled challenge with tartrazine.
A total of 102 subjects were enrolled in the study: 19 (18.6%) showed at least one relevant positive reaction to an IgE test for food allergy. Only one subject (1%) had reactions after ingestion of 5 mg of tartrazine, given on day 5. She did not have adverse reactions to placebo.
This study shows that the percentage of acute urticaria and/or angioedema induced by tartrazine is very low (1%). In view of our results, we suggest that all physicians with patients who have suffered adverse reactions that could be attributed to tartrazine should also carefully evaluate other possible causes.
酒石黄常与多种疾病相关。然而，酒石黄在这些疾病，尤其是荨麻疹中的因果关系尚未完全确立。
本研究旨在确定在摄入含有该物质的餐食或产品后出现急性荨麻疹/血管性水肿发作的受试者中酒石黄不耐受的发生率。
这是一项回顾性研究，基于对报告在摄入含有酒石黄的餐食或产品后出现荨麻疹和/或血管性水肿发作的患者数据的分析。在首次门诊就诊时，进行了详细的问诊。然后，患者接受了以下诊断测试：针对常见吸入性过敏原和食物过敏原的IgE测试以及酒石黄的双盲安慰剂对照激发试验。
共有102名受试者参与本研究：19名（18.6%）对食物过敏的IgE测试显示至少有一项相关阳性反应。仅一名受试者（1%）在第5天摄入5毫克酒石黄后出现反应。她对安慰剂无不良反应。
本研究表明，酒石黄诱发的急性荨麻疹和/或血管性水肿的百分比非常低（1%）。鉴于我们的研究结果，我们建议所有诊治可能归因于酒石黄不良反应患者的医生也应仔细评估其他可能的病因。
