性腺中抗苗勒管激素信号通路的组成部分。

Components of the anti-Müllerian hormone signaling pathway in gonads.

作者信息

di Clemente N, Josso N, Gouédard L, Belville C

机构信息

Unité INSERM 493, 32 rue des Carnets, Clamart 92140, France.

出版信息

Mol Cell Endocrinol. 2003 Dec 15;211(1-2):9-14. doi: 10.1016/j.mce.2003.09.005.

DOI:10.1016/j.mce.2003.09.005

PMID:14656470

Abstract

Anti-Müllerian hormone (AMH) is a member of the Transforming Growth Factor-beta (TGF-beta) family implicated in the regression of Müllerian ducts in male fetuses and in the development and function of gonads of both sexes. Members of the TGF-beta family signal through two types of serine/threonine kinase receptors called type I and type II, and two types of Smad proteins, receptor-regulated Smad (R-Smad) and common Smad, Smad4. Components of the AMH signaling pathway have been identified in gonads and gonadal cell lines. The AMH type II receptor is highly specific. In contrast, the identity of the AMH type I receptor is not clear; three type I receptors of Bone Morphogenetic Proteins (BMPs), Alk2, Alk3 and Alk6 may transduce AMH signals, but none of them has all the characteristics of an AMH type I receptor. AMH activates BMP-specific R-Smads and reporter genes.

摘要

抗苗勒管激素（AMH）是转化生长因子-β（TGF-β）家族的成员，与男性胎儿苗勒管的退化以及两性性腺的发育和功能有关。TGF-β家族成员通过两种类型的丝氨酸/苏氨酸激酶受体（I型和II型）以及两种类型的Smad蛋白（受体调节型Smad，即R-Smad和共同型Smad，Smad4）进行信号传导。AMH信号通路的组成成分已在性腺和性腺细胞系中得到鉴定。AMH II型受体具有高度特异性。相比之下，AMH I型受体的身份尚不清楚；骨形态发生蛋白（BMP）的三种I型受体Alk2、Alk3和Alk6可能传导AMH信号，但它们都不完全具备AMH I型受体的所有特征。AMH可激活BMP特异性R-Smads和报告基因。