Levy Daniel A, Manns Joseph R, Hopkins Ramona O, Gold Jeffrey J, Broadbent Nicola J, Squire Larry R
Veterans Affairs Healthcare System, San Diego, California 92161, USA.
Learn Mem. 2003 Nov-Dec;10(6):531-6. doi: 10.1101/lm.66703.
In a recent study, rats with hippocampal lesions performed as well as did unoperated rats on an olfactory memory span task, performing approximately 80% correct even when the span length reached 24 odors. This finding seems potentially at odds with demonstrations that memory-impaired patients typically fail tasks in which large amounts of information must be retained. Accordingly, we have assessed recognition memory span performance for line drawings of objects, designs, and odors in amnesic patients with damage thought to be limited to the hippocampal region. The patients were impaired on all three tasks. We consider possible explanations for the difference between the findings for humans and rats, including the fact that olfactory function is particularly well-developed in rodents.
在最近一项研究中，海马体受损的大鼠在嗅觉记忆广度任务中的表现与未做手术的大鼠一样好，即使跨度长度达到24种气味时，正确率仍约为80%。这一发现似乎与以下证明存在潜在矛盾：记忆受损的患者通常在必须保留大量信息的任务中表现不佳。因此，我们评估了被认为仅海马体区域受损的失忆症患者对物体、图案和气味的线条图的识别记忆广度表现。这些患者在所有这三项任务中均表现受损。我们考虑了人类和大鼠研究结果差异的可能解释，包括嗅觉功能在啮齿动物中特别发达这一事实。
