Yonelinas Andrew P, Kroll Neal E A, Quamme Joel R, Lazzara Michele M, Sauvé Mary-Jane, Widaman Keith F, Knight Robert T
Department of Psychology, University of California, Davis, California 95616, USA.
Nat Neurosci. 2002 Nov;5(11):1236-41. doi: 10.1038/nn961.
Memory for past events can be based on recollection or on assessments of familiarity. These two forms of human memory have been studied extensively by philosophers and psychologists, but their neuroanatomical substrates are largely unknown. Here we examined the brain regions that are involved in these two forms of memory by studying patients with damage to different temporal lobe regions. Our results come from (i) structural covariance modeling of recall and recognition, (ii) introspective reports during recognition and (iii) analysis of receiver operating characteristics. In sum, we found that the regions disrupted in mild hypoxia, such as the hippocampus, are centrally involved in conscious recollection, whereas the surrounding temporal lobe supports familiarity-based memory discrimination.
对过去事件的记忆可以基于回忆或熟悉度评估。哲学家和心理学家对人类记忆的这两种形式进行了广泛研究，但它们的神经解剖学基础在很大程度上仍不为人知。在这里，我们通过研究不同颞叶区域受损的患者，考察了参与这两种记忆形式的脑区。我们的研究结果来自于：（i）回忆和识别的结构协方差建模，（ii）识别过程中的内省报告，以及（iii）接受者操作特征分析。总之，我们发现，在轻度缺氧时受到破坏的区域，如海马体，在有意识回忆中起核心作用，而周围的颞叶则支持基于熟悉度的记忆辨别。
