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MED1: a central molecule for maintenance of genome integrity and response to DNA damage.

作者信息

Parsons Barbara L

机构信息

Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

出版信息

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14601-2. doi: 10.1073/pnas.2637169100. Epub 2003 Dec 1.

DOI:10.1073/pnas.2637169100
PMID:14657347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC299743/
Abstract
摘要

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本文引用的文献

1
The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity.碱基切除修复酶MED1介导对抗肿瘤药物的DNA损伤反应，并与错配修复系统完整性相关。
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15071-6. doi: 10.1073/pnas.2334585100. Epub 2003 Nov 12.
2
Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk(+/-) transgenic mice.Pms2基因缺陷导致Tk(+/-)转基因小鼠的次黄嘌呤磷酸核糖转移酶（Hprt）基因而非胸苷激酶（Tk）基因突变增加。
Mutagenesis. 2003 Jul;18(4):365-70. doi: 10.1093/mutage/geg007.
3
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis.Fas相关死亡结构域蛋白与甲基化CpG结合结构域蛋白4相互作用：基因组监测与细胞凋亡之间的潜在联系。
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5211-6. doi: 10.1073/pnas.0431215100. Epub 2003 Apr 17.
4
DNA repair and tumorigenesis: lessons from hereditary cancer syndromes.DNA修复与肿瘤发生：来自遗传性癌症综合征的教训
Cancer Biol Ther. 2002 Sep-Oct;1(5):477-85. doi: 10.4161/cbt.1.5.160.
5
Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation.Mbd4基因失活会增加C→T转换突变并促进胃肠道肿瘤形成。
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14937-42. doi: 10.1073/pnas.232579299. Epub 2002 Nov 4.
6
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.MBD4基因缺陷小鼠中增强的CpG突变性与肿瘤发生
Science. 2002 Jul 19;297(5580):403-5. doi: 10.1126/science.1073354.
7
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis.五大DNA修复途径中的DNA修复/促凋亡双重作用蛋白：针对致癌作用的故障安全保护。
Mutat Res. 2002 Jun;511(2):145-78. doi: 10.1016/s1383-5742(02)00009-1.
8
Functional interactions and signaling properties of mammalian DNA mismatch repair proteins.哺乳动物DNA错配修复蛋白的功能相互作用及信号特性
Cell Death Differ. 2001 Nov;8(11):1076-92. doi: 10.1038/sj.cdd.4400948.
9
Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites.人类DNA错配修复在体外的运作独立于CpG位点的甲基化状态。
Nucleic Acids Res. 2001 Jun 1;29(11):2234-43. doi: 10.1093/nar/29.11.2234.
10
5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence.5-甲基胞嘧啶DNA糖基化酶活性也存在于人类MBD4（G/T错配糖基化酶）及相关鸟类序列中。
Nucleic Acids Res. 2000 Nov 1;28(21):4157-65. doi: 10.1093/nar/28.21.4157.